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Loss is a four-panel webcomic strip from Tim Buckley's gaming series Ctrl+Alt+Del, published on June 2, 2008, depicting a miscarriage scene that was so tonally jarring it became one of the internet's most enduring and widely parodied memes. The strip's simple visual layout, a single figure, two figures, two figures, and one standing with one lying down, was distilled into the minimalist notation "| || || |_" and hidden in countless images, objects, and artworks across the web. Recognizing the pattern became a game unto itself, spawning the catchphrase "Is this Loss?"

Math Lady, also called Confused Math Lady, is a reaction image and GIF featuring Brazilian actress Renata Sorrah as the villain Nazaré Tedesco from the 2004 telenovela *Senhora do Destino*. The image shows Sorrah with an intensely confused expression, often overlaid with floating mathematical equations, and is used to express bewilderment or overthinking. First used as a reaction GIF in 2013, it exploded internationally in 2016 after someone added math formulas to the screenshot, turning it into one of the most recognizable confusion memes on the internet.

Blinking White Guy is a reaction GIF of Drew Scanlon, a video producer at gaming website Giant Bomb, doing a subtle double-take during a 2013 livestream. The clip sat dormant for years before exploding on Twitter in February 2017, becoming one of the most-used GIFs on the internet for expressing disbelief, confusion, or a polite "what the hell?"[3]. Scanlon later used his accidental fame to raise tens of thousands of dollars for multiple sclerosis research[4].

"Karen" is a slang term and meme archetype describing an entitled, middle-class white woman known for demanding to speak to the manager, harassing service workers, and weaponizing privilege against people of color[1]. The meme coalesced from multiple internet trends between 2014 and 2018, drawing on Black American internet culture's tradition of satirizing racial hostility through commonplace names[1]. By 2020, "Karen" had become one of the most recognizable character archetypes on the internet, fueled by viral videos of real-world confrontations and the COVID-19 pandemic's mask wars[7].

Yeet is an exclamation and slang verb that exploded out of black social media culture in early 2014, first as a choreographed dance on Vine and YouTube before evolving into the internet's favorite word for throwing something with maximum force and zero concern. The word was voted the American Dialect Society's 2018 Slang/Informal Word of the Year and was added to Dictionary.com in 2021[2].

Modern Problems Require Modern Solutions is a reaction image meme featuring comedian Dave Chappelle pointing to his temple with a knowing expression. The screenshot comes from a 2004 episode of Chappelle's Show and went viral on Reddit in December 2018[2]. The format is used to caption clever, absurd, or questionable "solutions" to everyday problems.

Skibidi Toilet is an animated YouTube series created in February 2023 by DaFuq!?Boom! featuring singing toilets with men's heads battling humanoid figures called CameraHeads. The Source Filmmaker shorts pulled tens of millions of views per episode through 2023 and became a flashpoint in online debates about Gen Alpha media.

"This Is Fine" is a two-panel reaction image from KC Green's 2013 webcomic "On Fire," showing an anthropomorphic dog calmly sipping coffee in a burning room while saying "This is fine." Born from Green's personal struggles with depression and antidepressants, the comic became one of the most widely shared memes of the 2010s, used as shorthand for denial or forced calm in the face of obvious disaster[1]. The Atlantic called it "a work of near-endless interpretability," and its relevance kept growing through political crises, pandemics, and everyday stress for over a decade[13].