In January 2012, YouTuber Xander Greene posted a video of a man performing the song live at a recital, reaching about 67,000 views over the next nine years3. On September 2nd, 2013, Animation Domination High Def, Fox's late-night animation block, released "Story From South America" with Davis, an official sequel about the same father and son working at a prison and arguing about killing or befriending escaped monkeys. The Flash-animated follow-up passed 2.7 million YouTube views but split fans of the original, many of whom preferred the pencil look of the first short.

The song came back into circulation on TikTok in mid-2020, when @waywardscientist posted the opening scene on May 23rd and reached about 2.5 million views. Sound edits followed quickly: @deepfacez placed it over footage of a dark liquid in a drain on June 11th (around 1.4 million views), and @nucleicacids attached it to a long-limbed modified Barbie doll on July 10th (roughly 4.9 million views)3. A year later, on May 18th, 2021, @robofizziepop clipped the darker verse where the spider kills the boy, drawing about 2.8 million views in a month.

Separately, one line, "What if the world was made of pudding?", spread as a stock reply to loaded hypotheticals after Neil Cicierega used it on Tumblr on February 8th, 2014 to answer an anonymous ask about political violence; that post picked up more than 92,000 notes4. The retort later reappeared on Twitter, including a July 25th, 2021 reply from @TransSalamander to a Daily Mail headline about an anti-trans book.